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Fortuna Arena, Prague
Wednesday 4 November, 8pm
Arsenal travel to Prague unbeaten in 18 Champions League games in normal time, a club record that survived a penalty shootout defeat to Paris Saint-Germain in last season's final, and a point or a win on Wednesday would stretch that run against a side they have never lost to in five previous European meetings.
Mikel Arteta's side go into the trip as reigning Premier League champions and current league leaders too, though the week has not been entirely smooth, with a shock EFL Cup exit at fourth-tier Fleetwood Town still fresh when Arsenal arrive at a Slavia Prague side chasing an elusive first continental win of the season.
Slavia Prague vs Arsenal form and preview
Arsenal have picked up seven points from three league phase games, beating Napoli away and Lille at home either side of that draw in Munich.
That return has them seventh of 36 sides in the competition, with a goal difference of plus four, while they also sit top of the Premier League on 24 points from nine matches, three clear of Manchester City.
Bukayo Saka and William Saliba are both out injured, and Arteta's selection has already been complicated this week by the manner of the Fleetwood Town defeat.
Four players who had missed recent matches through injury, Christos Tzolis, Declan Rice, Noni Madueke and Riccardo Calafiori, are all back in contention for Wednesday.
Slavia Prague could hardly be enjoying more contrasting fortunes across their two competitions this season.
Jindrich Trpisovsky's side sit seven points clear at the top of the Czech First League, a position that makes their European struggles all the more striking by comparison.
A single point from three league phase matches leaves them 32nd of 36, beaten at home by Lens and away at Sabah either side of that draw at Fenerbahce.
Three previous home meetings with Arsenal in European competition have produced three Slavia defeats and not a single goal for the hosts.
Top scorer Tomas Chory will play no part, dropped by the club roughly a fortnight ago after a fourth red card in two seasons, leaving Slavia reliant on a front line reshaped around Danijel Sturm and the returning Emmanuel Ayaosi.
Team news and predicted lineups: Slavia Prague vs Arsenal
Slavia Prague
Chory's exclusion is the headline absence, with Adonija Ouanda, Elias Pitak and Ivan Schranz all definitely missing too.
Goalkeeper Jakub Markovic's own muscle issue should open the door for Nazar Domchak to start between the posts, with Lukas Provod, Samuel Isife and Ange N'Guessan all doubtful.
Ayaosi, who is tied for the most goal involvements in the Slavia squad this season with four goals and two assists, is expected to feature alongside fellow Nigerians Mubarak Suleiman and David Moses in a reshaped forward line.
Slavia Prague predicted lineup vs Arsenal
Domchak; Holes, Zima, Chaloupek; Vlcek, Sadilek, Moses, Kubiak; Ayaosi, Suleiman; Nowak.
Arsenal
Saka picked up his quad injury in the Bayern Munich draw and is not expected back until the Brentford game in early December, while Saliba remains out with the back problem that has kept him sidelined since before that.
Eze is a doubt, leaving Arteta with a genuine selection puzzle in behind the striker.
Max Dowman is available despite serving a three match ban at home, since the suspension he picked up for his red card in the EFL Cup defeat at Fleetwood Town is a domestic sanction only and does not extend to the Champions League.
Christos Tzolis, Declan Rice, Noni Madueke and Riccardo Calafiori have all returned to full training after their own recent fitness concerns.
Arsenal predicted lineup vs Slavia Prague
Raya; Timber, Konsa, Gabriel, Calafiori; Rice, Guimaraes, Odegaard; Madueke, Havertz, Tzolis.
Head-to-head: Slavia Prague vs Arsenal
The sides have met five times, always in UEFA competition, and Arsenal are unbeaten with three wins and two draws.
Arsenal's joint biggest win in the whole of their European history came against this exact opponent, a 7-0 victory in the Champions League group stage back in October 2007, with the return fixture three weeks later finishing goalless.
The two sides also met in the 2021 Europa League quarter finals, when Tomas Holes, still part of this Slavia squad, scored the equaliser in a 1-1 draw at the Emirates Stadium before Arsenal won the second leg 4-0 in Prague.
A year ago to the week, Arsenal won the corresponding fixture 3-0 at Fortuna Arena through goals from Saka and a Mikel Merino brace, the night Dowman became the youngest player in Champions League history at 15 years and 308 days.
More broadly, Arsenal remain unbeaten in all 11 of their previous UEFA meetings against Czech opposition and have kept a clean sheet in all six of their away games in Czechia.
Our Slavia Prague vs Arsenal prediction and tips
Odds correct as of Monday, 2 November 2026, 19:55 GMT.
If you are weighing up your options for Wednesday's match and beyond, our round-up of the best new betting sites in the UK is worth a look, and anyone focused purely on the beautiful game can also check our guide to the best football gambling websites for markets across this fixture and the rest of the continental midweek.
For a broader spread of operators beyond this one match, our wider ranking of the best UK sports gambling sites covers the full market, while punters who fancy BoyleSports for this one can read our dedicated BoyleSports review before placing a bet.
- Likely scorers: Martin Odegaard, Kai Havertz
Adam is a freelance sports journalist with a decade of experience in the industry. Football is his passion, although he also follows darts and many other sports.
Adam supports Arsenal and local club Wealdstone, made famous by the Wealdstone Raider, who he has interviewed. Adam also follows the women's teams and the England national side.