| 1 | Lionel Messi
FC Barcelona | FC Barcelona | 35 | 30 |
| 2 | Gerard Moreno
Villarreal CF | Villarreal CF | 33 | 23 |
| - | Karim Benzema
Real Madrid | Real Madrid | 34 | 23 |
| 4 | Luis Suárez
Atlético Madrid | Atlético Madrid | 32 | 21 |
| 5 | Youssef En-Nesyri
Sevilla FC | Sevilla FC | 38 | 18 |
| 6 | Alexander Isak
Real Sociedad | Real Sociedad | 34 | 17 |
| 7 | Iago Aspas
RC Celta | RC Celta | 33 | 14 |
| 8 | José Luis Morales
Levante UD | Levante UD | 38 | 13 |
| - | Antoine Griezmann
FC Barcelona | FC Barcelona | 36 | 13 |
| - | Rafa Mir
SD Huesca | SD Huesca | 38 | 13 |
| 11 | Roger
Levante UD | Levante UD | 33 | 12 |
| - | Santi Mina
RC Celta | RC Celta | 34 | 12 |
| - | Marcos Llorente
Atlético Madrid | Atlético Madrid | 37 | 12 |
| - | Kike García
SD Eibar | SD Eibar | 37 | 12 |
| 15 | Borja Iglesias
Real Betis | Real Betis | 28 | 11 |
| - | Ante Budimir
CA Osasuna | CA Osasuna | 30 | 11 |
| - | Mikel Oyarzabal
Real Sociedad | Real Sociedad | 33 | 11 |
| - | Carlos Soler
Valencia CF | Valencia CF | 32 | 11 |
| - | Joselu
Deportivo Alavés | Deportivo Alavés | 37 | 11 |
| 20 | Roberto Soldado
Granada CF | Granada CF | 29 | 9 |
| - | Ángel Correa
Atlético Madrid | Atlético Madrid | 38 | 9 |
| - | Brais Méndez
RC Celta | RC Celta | 34 | 9 |
| 23 | Jorge Molina
Granada CF | Granada CF | 33 | 8 |
| - | Portu
Real Sociedad | Real Sociedad | 37 | 8 |
| - | Álvaro Negredo
Cádiz CF | Cádiz CF | 35 | 8 |
| - | Álex Berenguer
Athletic Club | Athletic Club | 35 | 8 |
| - | Sergio Canales
Real Betis | Real Betis | 31 | 8 |
| 28 | João Félix
Atlético Madrid | Atlético Madrid | 31 | 7 |
| - | Gonzalo Melero
Levante UD | Levante UD | 29 | 7 |
| - | Roberto Torres
CA Osasuna | CA Osasuna | 35 | 7 |
| - | Nolito
RC Celta | RC Celta | 36 | 7 |
| - | Maximiliano Gómez
Valencia CF | Valencia CF | 31 | 7 |
| - | Lucas Boyé
Elche CF | Elche CF | 34 | 7 |
| 34 | Sandro Ramírez
SD Huesca | SD Huesca | 20 | 6 |
| - | Paco Alcácer
Villarreal CF | Villarreal CF | 27 | 6 |
| - | Ousmane Dembélé
FC Barcelona | FC Barcelona | 30 | 6 |
| - | Shon Zalman Weissman
Real Valladolid | Real Valladolid | 32 | 6 |
| - | Fabián Orellana
Real Valladolid | Real Valladolid | 30 | 6 |
| - | Yannick Carrasco
Atlético Madrid | Atlético Madrid | 30 | 6 |
| - | Iñaki Williams
Athletic Club | Athletic Club | 38 | 6 |
| - | Fidel
Elche CF | Elche CF | 30 | 6 |
| - | Casemiro
Real Madrid | Real Madrid | 34 | 6 |
| 43 | Carlos Bacca
Villarreal CF | Villarreal CF | 23 | 5 |
| - | Manu Vallejo
Valencia CF | Valencia CF | 30 | 5 |
| - | Tello
Real Betis | Real Betis | 29 | 5 |
| - | Ángel
Getafe CF | Getafe CF | 33 | 5 |
| - | Jonathan Calleri
CA Osasuna | CA Osasuna | 25 | 5 |
| - | Luis Suárez
Granada CF | Granada CF | 27 | 5 |
| - | Raúl García
Athletic Club | Athletic Club | 34 | 5 |
| - | Marco Asensio
Real Madrid | Real Madrid | 35 | 5 |